CRM Publications

Heslop JA, Rowe C, Walsh J, Sison-Young R, Jenkins R, Kamalian L, Kia R, Hay DC, Jones RP, Malik HZ et al..  2017.  Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.Arch Toxicol. 91(1):439-452.

Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC.  2014.  Accurate prediction of Drug Induced Liver Injury using stem cell-derived populations.Stem Cells Transl Med. 3(2):141-8.

Guest RV, Boulter L, Kendall TJ, Minnis-Lyons SE, Walker R, Wigmore SJ, Sansom OJ, Forbes SJ.  2014.  Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma.Cancer Res. 74(4):1005-10.

Williams MJ, Clouston AD, Forbes SJ.  2014.  Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.Gastroenterology. 146(2):349-56.

Ahmad S, Sultan S, Naz N, Ahmad G, Alwahsh SMohammad, Cameron S, Moriconi F, Ramadori G, Malik IAhmed.  2014.  Regulation of iron uptake in primary culture rat hepatocytes: the role of acute-phase cytokines.Shock. 41(4):337-45.

Medine C.N, Lucendo-Villarin B, Storck C, Wang F, Szkolnicka D, Khan F, Pernagallo S, Black JR, Marriage HM, Ross JA et al..  2013.  Developing high-fidelity hepatotoxicity models from pluripotent stem cells.Stem Cells Transl Med. 2(7):505-9.

Greenhough S, Bradburn H, Gardner J, Hay DC.  2013.  Development of an embryoid body-based screening strategy for assessing the hepatocyte differentiation potential of human embryonic stem cells following single-cell dissociation.Cell Reprogram. 15(1):9-14.

Palakkan AA, Hay DC, Kumar PRAnil, Kumary TV, Ross JA.  2013.  Liver tissue engineering and cell sources: issues and challenges.Liver Int. 33(5):666-76.

Szkolnicka D, Zhou W, Lucendo-Villarin B, Hay DC.  2013.  Pluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology.Annu Rev Pharmacol Toxicol. 53:147-59.

Hay DC.  2013.  Rapid and scalable human stem cell differentiation: now in 3D.Stem Cells Dev. 22(20):2691-2.

Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Seo SSoo, Spee B, van Rooijen N et al..  2012.  Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.Nat Med. 18(4):572-9.

Forbes SJ, Newsome PN.  2012.  New horizons for stem cell therapy in liver disease.J Hepatol. 56(2):496-9.

Zhou W, Hannoun Z, Jaffray E, Medine C.N, Black JR, Greenhough S, Zhu L, Ross JA, Forbes SJ, Wilmut I et al..  2012.  SUMOylation of HNF4α regulates protein stability and hepatocyte function.J Cell Sci. 125(Pt 15):3630-5.

Payne C, Samuel K, Pryde A, King J, Brownstein D, Schrader J, Medine C.N, Forbes SJ, Iredale JP, Newsome PN et al..  2011.  Persistence of functional hepatocyte-like cells in immune-compromised mice.Liver Int. 31(2):254-62.

Hay DC, Pernagallo S, Diaz-Mochon JJose, Medine C.N, Greenhough S, Hannoun Z, Schrader J, Black JR, Fletcher J, Dalgetty D et al..  2011.  Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism.Stem Cell Res. 6(2):92-102.

Hay DC.  2010.  Cadaveric hepatocytes repopulate diseased livers: life after death.Gastroenterology. 139(3):729-31.

Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott RL, Clayton E, Andreone P, Bernardi M, Golding M et al..  2010.  Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver.Gut. 59(5):645-54.

Hannoun Z, Filippi C, Sullivan G, Hay DC, Iredale JP.  2010.  Hepatic endoderm differentiation from human embryonic stem cells.Curr Stem Cell Res Ther. 5(3):233-44.

Greenhough S, Medine C.N, Hay DC.  2010.  Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening.Toxicology. 278(3):250-5.

Stutchfield BM, Forbes SJ, Wigmore SJ.  2010.  Prospects for stem cell transplantation in the treatment of hepatic disease.Liver Transpl. 16(7):827-36.

Thomas JA, Forbes SJ.  2009.  A fat chance for hepatocyte transplantation?Gut. 58(4):480-2.

Dalgetty D, Medine C.N, Iredale JP, Hay DC.  2009.  Progress and future challenges in stem cell-derived liver technologies.Am J Physiol Gastrointest Liver Physiol. 297(2):G241-8.

Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, Black JR, Elcombe C, Ross JA, Wolf R et al..  2008.  Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.Stem Cells. 26(4):894-902.

Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RCJ, Snoeys J, Black JR, Wojtacha D, Samuel K, Hannoun Z et al..  2008.  Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.Proc Natl Acad Sci U S A. 105(34):12301-6.

Fletcher J, Cui W, Samuel K, Black JR, Hannoun Z, Currie IS, Terrace JD, Payne C, Filippi C, Newsome PN et al..  2008.  The inhibitory role of stromal cell mesenchyme on human embryonic stem cell hepatocyte differentiation is overcome by Wnt3a treatment.Cloning Stem Cells. 10(3):331-9.