CRM Publications

McGarvey AC, Rybtsov S, Souilhol C, Tamagno S, Rice R, Hills D, Godwin D, Rice D, Tomlinson SR, Medvinsky AL.  2017.  A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.J Exp Med. 214(12):3731-3751.

Imanirad P, Kartalaei PSolaimani, Crisan M, Vink C, Yamada-Inagawa T, de Pater E, Kurek D, Kaimakis P, van der Linden R, Speck N et al..  2014.  HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo.Stem Cell Res. 12(1):24-35.

Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MFTR, Ferguson-Smith AC et al..  2013.  Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.Haematologica. 98(2):163-71.

Fitch SR, Kimber GM, Wilson NK, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky AL, Dzierzak E, Ottersbach K.  2012.  Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis.Cell Stem Cell. 11(4):554-66.

Robin C, Ottersbach K, Boisset J-C, Oziemlak A, Dzierzak E.  2011.  CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.Blood. 117(19):5088-91.

Rybtsov S, Sobiesiak M, Taoudi S, Souilhol C, Senserrich J, Liakhovitskaia A, Ivanovs A, Frampton J, Zhao S, Medvinsky AL.  2011.  Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.J Exp Med. 208(6):1305-15.

Ivanovs A, Rybtsov S, Welch L, Anderson RA, Turner ML, Medvinsky AL.  2011.  Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region.J Exp Med. 208(12):2417-27.

Taylor E, Taoudi S, Medvinsky AL.  2010.  Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development.Int J Dev Biol. 54(6-7):1055-60.

Gordon-Keylock S, Jackson M, Huang C, Samuel K, Axton RA, Oostendorp RAJ, A Taylor H, Wilson J, Forrester LM.  2010.  Induction of hematopoietic differentiation of mouse embryonic stem cells by an AGM-derived stromal cell line is not further enhanced by overexpression of HOXB4.Stem Cells Dev. 19(11):1687-98.

He W, Nieponice A, Soletti L, Hong Y, Gharaibeh B, Crisan M, Usas A, Péault B, Huard J, Wagner WR et al..  2010.  Pericyte-based human tissue engineered vascular grafts.Biomaterials. 31(32):8235-44.

Bee T, Liddiard K, Swiers G, Bickley SRB, Vink CS, Jarratt A, Hughes J, Medvinsky AL, de Bruijn MFTR.  2009.  Alternative Runx1 promoter usage in mouse developmental hematopoiesis.Blood Cells Mol Dis. 43(1):35-42.

Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K.  2009.  Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.Blood. 114(21):4645-53.

Peeters M, Ottersbach K, Bollerot K, Orelio C, de Bruijn M, Wijgerde M, Dzierzak E.  2009.  Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.Development. 136(15):2613-21.

Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E.  2007.  Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.Proc Natl Acad Sci U S A. 104(52):20838-43.

Taoudi S, Medvinsky AL.  2007.  Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta.Proc Natl Acad Sci U S A. 104(22):9399-403.

Krassowska A, Gordon-Keylock S, Samuel K, Gilchrist D, Dzierzak E, Oostendorp R, Forrester LM, Ansell JD.  2006.  Promotion of haematopoietic activity in embryonic stem cells by the aorta-gonad-mesonephros microenvironment.Exp Cell Res. 312(18):3595-603.

Robin C, Ottersbach K, Durand C, Peeters M, Vanes L, Tybulewicz V, Dzierzak E.  2006.  An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.Dev Cell. 11(2):171-80.

Tavian M, Zheng B, Oberlin E, Crisan M, Sun B, Huard J, Péault B.  2005.  The vascular wall as a source of stem cells.Ann N Y Acad Sci. 1044:41-50.

Ling K-W, Ottersbach K, van Hamburg JPiet, Oziemlak A, Tsai F-Y, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E.  2004.  GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.J Exp Med. 200(7):871-82.

de Bruijn MFTR, Ma X, Robin C, Ottersbach K, Sanchez M-J, Dzierzak E.  2002.  Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.Immunity. 16(5):673-83.

Kumaravelu P, Hook L, Morrison AM, Ure J, Zhao S, Zuyev S, Ansell JD, Medvinsky AL.  2002.  Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver.Development. 129(21):4891-9.

Oostendorp RAJ, Harvey KN, Kusadasi N, de Bruijn MFTR, Saris C, Ploemacher RE, Medvinsky AL, Dzierzak E.  2002.  Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity.Blood. 99(4):1183-9.

Dzierzak E, Medvinsky AL, de Bruijn MFTR.  1998.  Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo.Immunol Today. 19(5):228-36.

Medvinsky AL, Dzierzak E.  1996.  Definitive hematopoiesis is autonomously initiated by the AGM region.Cell. 86(6):897-906.

Medvinsky AL, Gan OI, Semenova ML, Samoylina NL.  1996.  Development of day-8 colony-forming unit-spleen hematopoietic progenitors during early murine embryogenesis: spatial and temporal mapping.Blood. 87(2):557-66.