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CRM Publications

Found 25 results
Filters: Keyword is Gene Targeting  [Clear All Filters]
2012
Devoy A, Bunton-Stasyshyn RKA, Tybulewicz VLJ, Smith AG, Fisher EMC.  2012.  Genomically humanized mice: technologies and promises.Nat Rev Genet. 13(1):14-20.
2010
Meek S, Buehr M, Sutherland L, Thomson AJ, Mullins JJ, Smith AG, Burdon T.  2010.  Efficient gene targeting by homologous recombination in rat embryonic stem cells.PLoS One. 5(12):e14225.
2009
Tsakiridis A, Tzouanacou E, Rahman A, Colby D, Axton RA, Chambers I, Wilson V, Forrester LM, Brickman JM.  2009.  Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells.Nucleic Acids Res. 37(19):e129.
2007
Wallace HAC, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, Hughes J, Wood WG, Higgs DR, Smith AG.  2007.  Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.Cell. 128(1):197-209.
2006
Mee PJ, O'Brien CM, Thomson H, van der Sar S, Lakics V, Allsopp TE.  2006.  Embryonic stem cells as a source of differentiated neural cells for pharmacological screens.Methods Mol Biol. 329:353-69.
Prokhortchouk A, Sansom OJ, Selfridge J, Caballero IM, Salozhin S, Aithozhina D, Cerchietti L, Meng FGuo, Augenlicht LH, Mariadason JM et al..  2006.  Kaiso-deficient mice show resistance to intestinal cancer.Mol Cell Biol. 26(1):199-208.
Samokhvalov IM, Thomson AM, Lalancette C, Liakhovitskaia A, Ure J, Medvinsky AL.  2006.  Multifunctional reversible knockout/reporter system enabling fully functional reconstitution of the AML1/Runx1 locus and rescue of hematopoiesis.Genesis. 44(3):115-21.
2004
Tse E, Smith AG, Hunt S, Lavenir I, Forster A, Warren AJ, Grutz G, Foroni L, Carlton MBL, Colledge WH et al..  2004.  Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.Mol Cell Biol. 24(5):2063-73.
2003
Testa G, Zhang Y, Vintersten K, Benes V, Pijnappel WWMPim, Chambers I, Smith AG, Smith AG, A Stewart F.  2003.  Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.Nat Biotechnol. 21(4):443-7.
Cornish VA, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M, Priddle H, Smith AG, Sim E.  2003.  Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene.Pharmacogenomics J. 3(3):169-77.
2001
Davies B, Kearns IR, Ure J, Davies CH, Lathe R.  2001.  Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.J Neurosci. 21(18):6993-7000.
Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schöfer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A et al..  2001.  Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.Cell. 107(3):323-37.
Rose K, Allan A, Gauldie S, Stapleton G, Dobbie L, Dott K, Martin C, Wang L, Hedlund E, Seckl JR et al..  2001.  Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation.J Biol Chem. 276(26):23937-44.
O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T.  2001.  The polycomb-group gene Ezh2 is required for early mouse development.Mol Cell Biol. 21(13):4330-6.
1999
Pagès G, Guérin S, Grall D, Bonino F, Smith A, Anjuere F, Auberger P, Pouysségur J.  1999.  Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice.Science. 286(5443):1374-7.
1998
De Felipe C, Herrero JF, O'Brien JA, Palmer JA, Doyle CA, Smith AG, Laird JM, Belmonte C, Cervero F, Hunt SP.  1998.  Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.Nature. 392(6674):394-7.
Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH et al..  1998.  Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.Nature. 396(6710):433-9.
Steel M, Moss J, Clark KA, Kearns IR, Davies CH, Morris RG, Skarnes WC, Lathe R.  1998.  Gene-trapping to identify and analyze genes expressed in the mouse hippocampus.Hippocampus. 8(5):444-57.
1996
Clark AF, Sharp MG, Mullins JJ.  1996.  Gene targeting and its application to basic hypertension research.Clin Sci (Lond). 90(6):435-46.
Forrester LM, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, Joyner AL, Wurst W.  1996.  An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.Proc Natl Acad Sci U S A. 93(4):1677-82.
Tate P, Skarnes W, Bird A.  1996.  The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse.Nat Genet. 12(2):205-8.
Lathe R.  1996.  Mice, gene targeting and behaviour: more than just genetic background.Trends Neurosci. 19(5):183-6;discussion188-9.
1995
Cui W, Fowlis DJ, Cousins FM, Duffie E, Bryson S, Balmain A, Akhurst RJ.  1995.  Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.Genes Dev. 9(8):945-55.
Smith AG, De Sousa MA, Kwabi-Addo B, Heppell-Parton A, Impey H, Rabbitts P.  1995.  A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.Nat Genet. 9(4):376-85.
1994
Grant SG.  1994.  Gene targeting and synaptic plasticity.Curr Opin Neurobiol. 4(5):687-92.